Anti Ischemic Effects of Abciximab in Angioplasty and Stenting Patients
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
AIR STUDY
TITLE: Anti-Ischemic effects of Abciximab(Reopro)
PATIENT POPULATION: Patients undergoing PCI(an interventional procedure placing a small
stent/metallic tube to keep a narrowed artery in your heart open) and either on a stable
statin dose or not on a statin. Statin= cholesterol lowering drug(ie, lipitor, zocor).
INTERVENTION: Heparin vs. heparin + abciximab during PCI
PURPOSE: Measure the effects of abciximab on special healing blood stem cells
(EPC's-Endothelial Progenitor Cells), on inflammation, on oxidative stress and on
microvascular blood flow.
PATIENT ASSESSMENT:
1. 50ccs blood draw on day 1(from sheath), day 2 ,day 7 and day 28.
2. Measurement of blood flow in selected suitable patients
3. 10 minute questionnaire before discharge and on visit on day 28.
Details
Lead Sponsor:
Emory University
Treatments:
Abciximab Antibodies, Monoclonal Immunoglobulin Fab Fragments