Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)
Status:
Completed
Trial end date:
1995-01-01
Target enrollment:
Participant gender:
Summary
Investigators with the goal of optimizing glycemic and blood pressure control saw type 1
diabetic patients weekly. A control group received 3-4 subcutaneous insulin injections per
day; an intravenous insulin pulsed infusion group received, in addition, three one hour
infusions in a pulsatile fashion over one eight hour period each week. Patients were followed
for 12 months with periodic testing of renal function by repeated blood and urinary analyses;
diabetes control by blood testing and diabetes impact measurement score; cardiac and
autonomic function by echocardiography, 24 hour electrocardiographic testing; and visual
changes with repeated fundus photography. The study hypothesis was that correction of
respiratory quotient would correct the defect leading to microvascular complications of
diabetes (Type 1).