Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients
Status:
Unknown status
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal
dialysis (PD) for long period of time. Although the exact mechanisms of peritoneal damage
during PD still remain unclear, generation of reactive oxygen species may be responsible for
progressive membrane dysfunction. N-acetylcysteine (NAC)is a powerful antioxidant shown to
protect peritoneal fibrosis in peritoneal dialysis animal model. In this study the
researchers investigated the hypothesis that NAC protect peritoneal membrane damage.