Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.

• Status: Terminated
• Trial end date: 2007-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Determine the best strategy for proteinuria lowering in patients with proteinuria > 1 g/day receiving ACEI and ARB combination: either increase of ACEI and ARB dosage or increase of diuretic dosage.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital
• Treatments: Diuretics; Furosemide; Ramipril; Valsartan

Criteria

Inclusion Criteria:

• proteinuria > 1 g/day with ramipril 5 + valsartan 80 mg/day for 2 months

• proteinuria changes < 50% on 3 separate dosages over 2 months.

Exclusion criteria:

• age < 18 or > 80 years systolic BP < 110 or ≥ 140 mmHg, serum creatinine > 250 mmole/L

• serum creatinine increase on ramipril + valsartan > 20%

• intolerance to ACEI or ARB