Anti-Secretory Drug in Treatment of Acute Watery Diarrhea

• Status: Completed
• Trial end date: 2018-08-31
• Target enrollment: 0
• Participant gender: All

Summary

In conclusion, racecadotril is an anti-secretory drug that exerts its antidiarrheal effect by inhibiting intestinal enkephalinase. It is effective in reducing the volume and frequency of stool output. racecadotril is well tolerated and safe by providing symptomatic relief and reducing the severity of diarrhea as an adjuvant therapy during the acute attack of gastroenteritis. It is recommended that the new generations of already discovered drugs for control of secretory diarrhea should be studied to discover the ones with fewer side effects to other systems in the body.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Racecadotril

Criteria

Inclusion Criteria:

• Age group for six months - 5 years.

• No or mild to moderate dehydration.

• Alert patient (to tolerate oral intake since the drug is only available in oral form).

Exclusion Criteria:

• Patients with severe dehydration (inability to drink because of drowsiness).

• Patients with any serious concomitant illness that needs antibiotic treatment.

• If severe adverse events occur at any time.

• Chronic diarrhea.