Anti-infective Effect of Non-surgical Treatment With and Without Photodynamic Therapy on Initial Peri-implantitis
Status:
Completed
Trial end date:
2019-05-01
Target enrollment:
Participant gender:
Summary
Photodynamic therapy (PDT), also known as photoradiation therapy, phototherapy, or
photochemotherapy, involves the use of a photoactive dye (photosensitizer) that is activated
by exposure to light of a specific wavelength in the presence of oxygen. In recent years, PDT
has been introduced as an important novel disinfection therapy in the field of implant
dentistry. The inactivation of microorganisms using PDT has been defined as antimicrobial
PDT. PDT has the potential to be an alternative of antibiotics, especially for the treatment
of localized infections and oral biofilm. PDT is unlikely to cause bacterial-resistance and
is equally effective against antibiotic-resistance and antibiotic-susceptible bacteria.
Inconsistent results have been reported regarding the potential role of PDT as an adjunct to
mechanical debridement in the management of peri-implant infection. Thus, the aim of the
present trial is to investigate the treatment effect of non-surgical treatment with and
without photodynamic therapy on initial peri-implantitis.
Phase:
Phase 3
Details
Lead Sponsor:
Shanghai 9th People's Hospital Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University