Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Hypothesis:
Prucalopride can mimic electrical stimulation of the abdominal vagus nerve and has an
anti-inflammatory effect.
Aims:
In the present pilot study, the investigators want to evaluate the anti-inflammatory effect
of prucalopride. The following aims are formulated:
1. to show that prucalopride has a similar inflammatory effect as abdominal vagus nerve
stimulation (VNS)
2. to evaluate whether prucalopride leads to accelerated post-operative recovery