Antibiotic Prophylaxis in Bariatric Surgery With Cefazolin: Concentration in Adipose Tissue
Status:
Completed
Trial end date:
2012-05-01
Target enrollment:
Participant gender:
Summary
Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented
with 1g delivered through continuous infusion during surgery. Adipose samples, obtained at
the beginning and end of surgery, were analyzed using high performance liquid chromatography.
Some published studies suggest that the dose of 2g does not supply the minimum inhibitory
concentration for principal causal agents of surgical site infection.
To determine the concentration of Cefazolin in adipose tissue of patients undergoing
bariatric surgery and to evaluate the relationship between concentrations obtained and body
mass index (BMI).