Overview

Antibiotic Prophylaxis in Children With Pyelonephritis

Status:
Withdrawn

Trial end date:
2014-12-01

Target enrollment:
0

Participant gender:
All

Summary

Children who present with pyelonephritis undergo many investigations, and long term care to prevent renal damage. The focus is primarily on preventing renal failure however along the way and particularly with children, other issues arise which impact their lives, as well as their family's lives. Parents are concerned about subjecting their children to invasive procedures and long term antibiotic use, particularly if they are not sure of the benefit. This study seeks to provide information on the impact of investigation and long term antibiotic treatment in reference to long term health and quality of life in children who present with febrile urinary tract infections in the absence of anatomic abnormalities.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

University of Alberta

Collaborator:

Canadian Urological Association

Treatments:

Amoxicillin
Anti-Bacterial Agents
Antibiotics, Antitubercular
Nitrofurantoin
Sulfamethoxazole
Trimethoprim
Trimethoprim, Sulfamethoxazole Drug Combination

Criteria

Inclusion Criteria:

- Children 0 to 12 years of age presenting with first episode of acute pyelonephritis in
the absence of vesicoureteral reflux.

- Acute pyelonephritis defined as presence of fever, a positive urine culture (growth of
a single urinary tract pathogen at =10(8) CFU/ml for catheterization specimens and
=10(4) CFU/ml for clean catch specimens), and a positive DMSA scan (a discreet defect
or generalized decrease in activity).

Exclusion Criteria:

- Neurogenic bladder

- anatomic congenital anomaly

- allergy to all prophylactic antibiotics

- children whose parents do not wish to participate