Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial
Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
The Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty (TKA):
Multi-Center Trial is a study that will compare the effectiveness of various perioperative
strategies for antibiotic delivery as prophylaxis for periprosthetic joint infections (PJI)
and surgical site infection in elective primary TKA. The investigators hypothesize that a
single dose of prophylactic antibiotic administered within 60 minutes before the incision is
not an effective way to prevent PJI in elective primary total knee arthroplasty (TKA). The
investigators also hypothesize that the prolonged delivery (24 hours) of antibiotic
prophylaxis after surgery does not further reduce the incidence of PJI in elective primary
TKA.
Duke University is the only site recruiting both primary total knee arthroplasty and
unilateral knee arthroplasty.
Phase:
Phase 4
Details
Lead Sponsor:
Duke University
Collaborators:
American Association of Hip and Knee Society American Association of Hip and Knee Surgeons Orthopedic Research and Education Foundation