Antibiotic Prophylaxis in Pediatric Open Fractures

• Status: Enrolling by invitation
• Trial end date: 2034-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This research will involve a prospective study on infection rates after grade 1 or 2 open fractures in the skeletally immature pediatric population. There will be 3 arms: one dose intravenous cefazolin, 24 hours intravenous cefazolin, and 24 hours intravenous cefazolin plus 5 days of oral cephalexin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Louis University
• Treatments: Cefazolin; Cephalexin

Criteria

Inclusion Criteria:

• Pediatric patients ages 0-17 years old

• Skeletally immagure patients, as confirmed by xray imaging evaluated by an orthopaedic surgeon

• Patient as sustained a grade 1 or 2 open fracture within 24 hours of presentation

• Physician plans to manage the fracture non-operatively

Exclusion Criteria:

• Patients 18 years or older

• Skeletally mature patients, as as confirmed by xray imaging evaluated by an orthopaedic surgeon

• Patients with grade 3 open fractures

• Gross contamination of the fracture

• Fracture requires surgery

• Immunocompromised patients

• Allergies to cephalosporins

• Severe penicillin allergy

• non-English speaking patients &/or guardian