Antibiotic Treatment in Ventilator Associated Tracheobronchitis (VAT)

• Status: Unknown status
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Mechanically Ventilated patients in the intensive care unit (ICU) often present with fever, and purulent sputum, but without radiological evidence of pneumonia.

These patients may have tracheobronchitis. Some suspect that this condition precedes the development of pneumonia. Antibiotic treatment in tracheobronchitis is controversial.

The investigators will recruit patients with tracheobronchitis and randomize them into 2 groups. One group will be treated with antibiotics and the other group will serve as control.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assaf-Harofeh Medical Center
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam

Criteria

Inclusion Criteria:

• Tracheobronchitis as defined by:

• Purulent sputum with > 10 x 4 CFU

• Leukocytosis or leukopenia

• Fever

• No pneumonia on CT scan

Exclusion Criteria:

• Recent treatment of pneumonia

• Abnormal Chest X-ray

• Evidence of Pneumonia on CT scan