Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

• Status: Completed
• Trial end date: 2020-09-20
• Target enrollment: 0
• Participant gender: All

Summary

Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics. The use of probiotics has been proposed in the literature as an adjunct therapy for the treatment of periodontal diseases, however, few controlled and randomized clinical studies have been performed. The objective of this double-blind randomized controlled trial will be to evaluate the response of clinical and microbiological periodontal parameters to the comparison of two different adjuvant therapies (antibiotic and probiotic) for the treatment of stages II and III grade B periodontitis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Metronidazole

Criteria

Inclusion Criteria:

• Individuals between 35 and 50 years of age;

• Be diagnosed with generalized chronic periodontitis: present a loss of interproximal clinical insertion> 3 mm in 2 nonadjacent teeth and loss of interproximal clinical insertion ≥5 mm, in 30% or more of the teeth present;

• Present at least 16 teeth;

• Present good systemic health;

• Agree to participate in the study and sign the informed consent form

Exclusion Criteria:

• Patients with systemic problems (cardiovascular changes, blood dyscrasias, immunodeficiency, among others), which do not indicate the periodontal procedure;

• Have undergone periodontal treatment in the last twelve months;

• Have used antibiotics and/or anti-inflammatories for the past six months;

• Smoking patients;

• Pregnancy or Lactation;

• Chronic use of medications that may alter the response of periodontal tissues.