Antibiotics Prior to Mini-screw Implant Insertion

• Status: Completed
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators plan to use amoxicillin in capsule form, prepared by a pharmacist, for antibiotic prophylaxis to decrease the failure rate of mini-screw implants temporarily placed in the palate of patients involved in Phase II orthodontics treatments. The mini-screws will be 8 mm long 1.7 mm diameter titanium screws manufactured by Forestadent and are commercially available and currently widely used in orthodontic treatment in both private practice and educational settings. Since antibiotic prophylaxis is considered the standard of care with traditional dental implants, the investigators believe that such prophylaxis will decrease the failure rate of orthodontic mini-screw implants also.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Louis University
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria: Subjects will be selected for the study based on treatment plans for Phase II orthodontics at SLU CADE orthodontics program, which require the use of palatally placed mini-screw implants for anchorage control.

Exclusion Criteria:

• Patients with experience in previous MSI placements

• allergy to amoxicillin

• allergy to Beta-lactam based antibiotics

• medical syndrome diagnoses

• psychiatric disorders (ADHD, autism, manic-depressive disorder, etc.)

• a compromised immune system

• impaired or decreased kidney function

• Type I or Type II diabetes

• patients taking Probenicid or Allopurinol