Antibiotics Versus Surgery in Acute Appendicitis

• Status: Unknown status
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The acute appendicitis (AA) is a very common disease with a life time risk 7-8% and the highest incidence in the second decades . The aetiology of AA is still poor understood: the commonest hypothesis refers to appendix obstruction followed by impairment of wall appendix barrier and thus wall perforation and/or abscess formation1. However some studies suggest that no-complicate and complicate appendicitis are different entities allowing a different treatment. The study aims to test the no inferiority in terms of efficacy of antibiotic treatment compared to surgery in a population with high probability to suffer of 1st episode of AA.The study aims to test the no inferiority in terms of efficacy of antibiotic treatment compared to surgery in a population with high probability to suffer of 1st episode of AA.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: A.O. Ospedale Papa Giovanni XXIII
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ertapenem

Criteria

Inclusion Criteria:

• patients between 18 and 65 years old

• first episode of suspected AA diagnosed by Andersson's score or combination with abdominal ultrasound

Exclusion Criteria:

• patients with any potential immunodeficiency status

• assumption of antibiotics for different infectious disease or surgery in the last 30 days

• allergy to antibiotics established in the study protocol

• no acceptance of study protocol

• pregnancy or delivery in the last 6 months

• ASA IV or V, no Italian or English fluently speakers.