Antidepressant Response in Older Adults With Comorbid PTSD and MDD

• Status: Recruiting
• Trial end date: 2026-03-01
• Target enrollment: 0
• Participant gender: All

Summary

In the Investigator's ongoing studies of Posttraumatic Stress Disorder (PTSD) in older adults, it has been found that older adults with PTSD frequently meet the criteria for comorbid Major Depressive Disorder (MDD). Moreover, relative to trauma-exposed healthy controls (TEHCs), elders with PTSD manifest executive function deficits, fatigability, and mobility and physical function deficits that are consistent with what the investigator has observed in depressed older adults. Yet, the investigator has found that very few older adults with combined PTSD/MDD have received appropriate antidepressant treatment for their condition. These findings give rise to the questions of (1) how effective is antidepressant treatment for depressive symptoms in the context of PTSD/MDD and (2) are cognitive and physical function deficits in PTSD/MDD patients reversible with effective antidepressant treatment?

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborator: Columbia University
• Treatments: Citalopram; Duloxetine Hydrochloride

Criteria

Inclusion Criteria:

1. Individual has completed IRB 7489

2. Diagnosed with DSM 5 MDD

3. HRSD >=18

4. Willing to and capable of providing informed consent and complying with study procedures.

Exclusion Criteria:

1. History of allergic or adverse reaction to

2. Non-response to adequate trial of escitalopram (at least 4 weeks at dose of 20mg) and duloxetine (at least 4 weeks at dose of 60mg)during the current episode.

3. Current treatment with psychotherapy, antidepressants, or other psychotropic medications.