Antifungal Prophylaxis in Intensive Care Unit (ICU) Patients
Status:
Completed
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
Purpose. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida
colonization and infection. However, Candida prophylaxis in intensive care unit (ICU) is
still a matter of debate.
Methods. Randomized, single-center trial studying single drug (nystatin) versus control in
surgical ICU patients. Multiple-site testing for fungi were performed in each patient at ICU
admission (T0) and subsequently every 3 days (T3, T6, T9…). The primary evaluation criterion
was the time course of colonization index (CI) during ICU stay.