Overview

Antihypertensive Effect of Simvastatin in Hypertensive Patients

Status:
Unknown status
Trial end date:
2009-09-01
Target enrollment:
0
Participant gender:
All
Summary
Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive effect may explain part of the favorable results of the Statins use on cardiovascular prevention independently from its action on the cholesterol profile. The purpose of this study is to determine the effect of Simvastatin on the blood pressure
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Treatments:
Antihypertensive Agents
Simvastatin
Criteria
Inclusion Criteria:

- Hypertensive patients with controlled or uncontrolled blood pressure

Exclusion Criteria:

- Secondary causes of hypertension;

- Systolic Blood pressure >= 180 mmHg and/or diastolic blood pressure >= 110 mmHg

- Complain of side effects related to Statins

- Diabetes

- Established target-organ damage (myocardial infarction, stroke, angina, heart failure,
peripheral vascular disease)

- Renal disease (creatinine > 1,5 mgdl).