Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission. Targeting this parasite reservoir before the transmission season could be a good strategy for malaria control. We are conducting a randomized double blind placebo controlled mass drug administration trial in eight village to clear the dry season low level parasitaemia with an ultimate aim of controlling malaria in eastern Sudan.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tropical Medicine Research Institute
• Collaborators: International Atomic Energy Agency; London School of Hygiene and Tropical Medicine
• Treatments: Artesunate; Pyrimethamine; Sulfadoxine

Criteria

Inclusion Criteria:

• All residents of the 8 villages

Exclusion Criteria:

• Pregnancy

• History of allergy to sulfa drugs