Overview

Antimicrobial Photodynamic Therapy in Chronic Periodontitis and Diabetes Mellitus

Status:
Completed

Trial end date:
2021-02-01

Target enrollment:
0

Participant gender:
All

Summary

With this design, this study hypothesizes that; (i) ICG-PDT would produce superior clinical, microbiological, and immune-inflammatory outcomes as compared to RSD and (ii) ICG-PDT would produce equal efficacy among different forms of diabetes as produced in non-diabetic subjects and that diabetes mellitus would not produce negative impact on the therapeutic outcomes of ICG-PDT. Therefore, the aim of this randomized controlled clinical trial was to evaluate the efficacy of ICG-mediated aPDT in the treatment of stage III grade C periodontitis among patients with prediabetes, T2DM and non-diabetic subjects.

Phase:

Phase 2/Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

King Saud University

Criteria

Inclusion Criteria:

1. aged ≥30 years

2. clinically diagnosed with mild to moderate periodontitis

3. self-reported type-2 DM for ≥2 years confirmed by a physician with HbA1c levels ≥6.5%

4. patients who complied with the treatment protocol.

Exclusion Criteria:

(i) pregnancy and lactation (ii) who had taken antibiotics in the previous 3 months (iii)
who had undergone periodontal therapy or any decontamination treatment in their oral cavity
in the previous 6 months (iv) former/current smokers (v) failure to provide a signed
informed consent.