Antimicrobial Prophylaxis in Thyroid and Parathyroid Surgery

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The effectiveness of antimicrobial prophylaxis (AMP) for prevention of surgical site infection (SSI) following thyroid and parathyroid surgery remains uncertain. Present prospective randomized control study (Ito-RCT1) assessed the effectiveness of AMP in clean neck surgery associated with thyroid and parathyroid disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ito Hospital
• Treatments: Anti-Infective Agents; Cefazolin; Piperacillin

Criteria

Inclusion Criteria:

• Between November 2010 and April 2012, 2164 consecutive patients who agreed to attend the randomized control study were enrolled. All the participants received surgery for thyroid and parathyroid disease at Ito Hospital.

Exclusion Criteria:

• Patients who did not agree to attend the randomized control study.

• Patients who received the operation including mediastinum with sternotomy.

• Patients who received the operation including additional resection of trachea, esophagus and larynx.

• Patients who received the re-operation for post-operative bleedings.

• Patients who had known allergy to cephem or penicillin.