Antioxidant Functions of Lipoic Acid

• Status: Completed
• Trial end date: 2007-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to determine whether a short treatment with lipoic acid, an antioxidant used in the treatment of diabetic neuropathy, improves blood vessel reactivity and decreases oxidant stress in persons with elevated blood cholesterol.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Center for Complementary and Integrative Health (NCCIH)
• Treatments: Antioxidants; Thioctic Acid

Criteria

Inclusion criteria:

• Lipid criteria for inclusion are a plasma LDL between 160 and 190 mg/dl (total cholesterol usually 240-285 mg/dl)

• Less than 2 coronary risk factors, and already on a cholesterol-lowering diet.

Exclusion criteria:

• Overt or clinical atherosclerosis

• Diabetes

• Currently taking cholesterol-lowering medication.

• Subjects with other lipid disorders

• Subjects taking supplemental lipoic acid, vitamin C, or vitamin E.