Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial
Status:
Terminated
Trial end date:
1996-06-01
Target enrollment:
Participant gender:
Summary
The trial was aimed at evaluating the efficacy of a multiagent antioxidant compound (vitamin
A, C, E, selenium and zinc) in reducing the incidence of metachronous adenomas of the large
bowel after endoscopic polypectomy. This is a randomized study: a 50% reduction in the
incidence of metachronous adenomas was expected in patients allocated to the "active"
compound (intervention) arm as compared to those assigned to a placebo.
Phase:
Phase 3
Details
Lead Sponsor:
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Collaborator:
LILT (Italian league against cancer)
Treatments:
Antioxidants Retinol palmitate Selenium Vitamin A Vitamins