Antiplaque, Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash

• Status: Completed
• Trial end date: 2018-12-15
• Target enrollment: 0
• Participant gender: All

Summary

Myrrh-based mouthwash has the potential to be a suitable alternative to the gold standard chlorhexidine mouthwash for dental plaque and gingivitis reduction. To date, however, little research has been carried out to determine its true clinical significance on periodontal health. The purpose of this study is to evaluate and compare the efficacy of 1% myrrh mouthwash with commercially available 0.2% chlorhexidine mouthwash in terms of plaque and gingivitis reduction and inflammatory mediator (interleukin-1β) inhibition.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: King Abdulaziz University
• Treatments: Chlorhexidine; Chlorhexidine gluconate

Criteria

Inclusion Criteria:

• good periodontal health;

• dentition of ≥20 teeth and a minimum of 5 teeth per quadrant;

• the absence of any systemic illness;

• no history of oral prophylaxis in the past 6 months;

• no relevant medical history that might compromise normal oral hygiene practice.

Exclusion Criteria:

• pocket depth >3 mm

• severe misalignment of teeth;

• the presence of orthodontic appliances;

• intake of antibiotic and/or anti-inflammatory medications within the past 6 months;

• use of tobacco;

• inability of comply with the study's appointment schedule;

• pregnant or breast-feeding mothers.