Antiplatelet and Anti-inflammatory Effects of Statins and Ezetimibe

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Among patients with stable coronary artery disease (CAD), it is not clear if the pleiotropic effects of cholesterol reduction differ between high-dose simvastatin alone and combined ezetimibe/simvastatin.

The investigators sought to compare the anti-inflammatory and anti-platelet effects of ezetimibe 10 mg / simvastatin 20 mg (E10/S20) to simvastatin 80 mg (S80).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Treatments: Anti-Inflammatory Agents; Ezetimibe; Simvastatin

Criteria

Inclusion Criteria:

• Stable angina

• Low-density lipoprotein (LDL) cholesterol 70-160 mg/dl

Exclusion Criteria:

• Renal failure

• Age>80

• Simvastatin current treatment>20mg

• Hepatic disease

• Inflammatory diseases