Antiseptic Effects on the Dental Implant Internal Surface Microbiome

• Status: Not yet recruiting
• Trial end date: 2023-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Madigan Army Medical Center
• Treatments: Chlorhexidine; Hydrogen Peroxide

Criteria

Inclusion Criteria:

• Active duty military

• 18-55 years old

• Over 6 months remaining at local duty station

Exclusion Criteria:

• Tobacco user

• Medications that affect soft tissue or bone healing

• Metabolic disorder that affects soft tissue or bone healing

• Active periodontal disease