Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
After thyroid surgery, the incidence and severity of coughing is important because it may
cause serious complications, such as bleeding in the surgical field, laryngospasm, and
cardiovascular disturbance. Several studies have shown that the single-dose of
dexmedetomidine is effective for reducing cough and agitation during emergence from general
anesthesia.
To test the hypothesis that single-dose of dexmedetomidine combined with a low-dose
remifentanil infusion during emergence from general anaesthesia could reduce coughing as good
as high-dose remifentanil infusion, we will evaluate the efficacy on cough suppression and
reduction of side effect of remifentanil using non-inferiority trial.
Phase:
Phase 4
Details
Lead Sponsor:
Yonsei University
Treatments:
Antitussive Agents Chlorpheniramine, phenylpropanolamine drug combination Dexmedetomidine Guaifenesin Phenylpropanolamine Remifentanil