Apneic Oxygenation Via Nasal Cannulae: 15 L/Min vs High-Flow

• Status: Completed
• Trial end date: 2018-06-22
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized clinical trial investigating the utility of apneic oxygenation via nasal cannulae in the post-induction setting for the purpose of prolonging the safe apneic time. Three groups will be compared, a control group at 0 L/min, a 15 L/min and a 60 L/min group. The primary outcome will be the difference in the partial pressure of oxygen in arterial blood (PaO2) between groups throughout the nine-minute apneic period.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nova Scotia Health Authority
• Collaborator: Dalhousie University

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists Physical Status Classification 1 to 3

• Body Mass Index 28 to 35

• Elective surgery under general anesthesia

Exclusion Criteria:

• Evidence of difficult airway management (from patient history or clinical examination)

• Features suggestive of difficult bag mask ventilation

• Significant uncontrolled gastroesophageal reflux disease

• Significant respiratory disease (including severe asthma or chronic obstructive pulmonary disease, oxygen dependency, pulmonary hypertension, identified by pulmonary function tests or inability to climb one flight of stairs)

• Significant cardiac disease (ischemic heart disease, severe valvular disease, severe arrhythmia, congestive heart failure, ejection fraction < 50%, inability to climb one flight of stairs)

• Inability to lie flat (skeletal deformities, orthopnea)

• Hemoglobin < 100 g/L

• Pregnancy

• Neuromuscular disorder

• Known or suspected cervical spine instability

• Patients undergoing neurosurgical procedures

• Any clinical or radiological evidence of increased intracranial pressure

• Any expected requirement for rapid sequence intubation

• Allergy to any of the agents used for induction of general anesthesia in the study

• Contraindication to insertion of radial artery cannula

• Uncorrected coagulopathy

• Significant nasal obstruction