Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancer

• Status: Unknown status
• Trial end date: 2019-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this clinical study is to evaluate the efficacy of lappaconitine adhesive patch in alleviation radiation induced mucositis pain and the improvements in QOL of patients with nasopharyngeal carcinoma . To determine if lappaconitine administered prior to radiation therapy reduces the severity of radiation induced oral mucositis pain in patients who have been diagnosed with nasopharyngeal carcinoma.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fujian Cancer Hospital
• Treatments: Aconitine; Lappaconitine

Criteria

Inclusion Criteria:

• Newly histologic diagnosis of nasopharyngeal carcinoma without distant metastasis

• Clinical stage III~IVa( UICC (Union International Against Cancer) /AJCC (American Joint Committee on Cancer) TNM staging system 8th edition)

• Karnofsky Performance Status Scale between 60-100

• WBC count ≥ 4×109/L，neutrophil differential count≥ 1.5×109/L,Hemoglobin ≥ 90g/L， platelet count ≥ 100×109/L

• ALT or AST ≤2.5×ULN,bilirubin ≤2.5×ULN,Serum creatinine ≤1.5×ULN or Serum creatinine clearance≥60ml/min

• Sign the informed consent.

Exclusion Criteria:

• Younger than 18 years old or older than 70 years old

• Pregnancy or lactation

• Severe cerebrovascular disease/canker/psychosis/uncontrolled diabetes

• Have suffered from other tumor or now suffering from other tumor

• Have suffered from oral diseases or salivary gland diseases or mow suffering from oral diseases or salivary gland diseases

• Refuse to give up smoking/drinking/betel chewing

• suffering from other active infection diseases and in need of treatment.