Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to understand, with the use of functional magnetic resonance imaging, the neural correlates involved in appetite control and the mechanism of weight gain in patients with schizophrenia treated with atypical antipsychotics. We hypothesize that a difference in cerebral activations between weight gaining and non-weight gaining patients will be detected after four months of treatment with olanzapine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Université de Montréal
• Collaborators: Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal; Centre de recherche Fernand-Seguin, Hôpital Louis-H. Lafontaine; Eli Lilly and Company; Hopital du Sacre-Coeur de Montreal
• Treatments: Antipsychotic Agents; Olanzapine

Criteria

Inclusion Criteria:

• Patients with schizophrenia (DMS-IV)

• 18 to 60 years old

• Right handed

• Begin a treatment with olanzapine and had not received it for at leat 6 months

• Other medication accepted (except antipsychotic)

Exclusion Criteria:

• concomitant axis-I or axis-II disorders

• unstable medical condition

• Concomitant antipsychotic medications