Applicability of PDOX in Patients With Primary Liver Cancer: A Randomized Controlled Trial

• Status: Recruiting
• Trial end date: 2026-01-30
• Target enrollment: 0
• Participant gender: All

Summary

This Randomized Controlled Trial was to clarity the clinical feasibility of PDOX results in guiding the drug use of interventional chemotherapy after primary liver cancer surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhujiang Hospital
• Treatments: Doxorubicin; Fluorouracil; Leucovorin; Oxaliplatin; Raltitrexed

Criteria

Inclusion Criteria:

1. Undergone radical surgical resection.

2. Aged 18-75.

3. Patients voluntarily cooperated with the study and signed an informed consent form.

4. Histopathologically diagnosed hepatocellular carcinoma.

5. Patients with R0 resection confirmed by imaging and pathology (no residual lesions and complete tumor resection after radical surgery).

6. Child-Pugh score of 5-7 (A or B), patients with a score of 7 must be free of ascites.

7. ECOG physical fitness status score of 0-1.

8. No serious heart, lung, or renal dysfunction

Exclusion Criteria:

1. Unable to provide specimens for PDOX testing.

2. Patients with recurrent liver cancer.

3. Developing two or more types of tumors simultaneously.

4. Patients with existing extrahepatic distant metastases.

5. Treatment with other experimental drugs or other interventions after radical resection.

6. Patients with other malignant tumors that have not been cured within 5 years.

7. Patients with non-radical resections (R1 and R2 resections).

8. Patients with residual or recurrent lesions detected on imaging within 1-2 months after surgery.

9. Died within 1 month after surgery.