Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
Status:
Recruiting
Trial end date:
2025-07-01
Target enrollment:
Participant gender:
Summary
The primary objective of this interventional study is determine if the future liver remnant
can be optimized by improving liver function pre-operatively in patients who are scheduled
for major hepatectomy. The main questions it aims to answer are:
1. Does high-dose insulin therapy improve liver function in the pre-operative setting?
2. What is the effect of high-dose insulin therapy on liver function and liver regeneration
after a liver venous deprivation (LVD) procedure?
3. What is the relationship between volume hypertrophy and function in the regenerating
liver? Participants will receive a 6-hour infusion of insulin and dextrose to maintain a
hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to
assess its effect on liver function measured by 99m-Tc-Mebrofenin hepatobiliary
scintigraphy.
Phase:
N/A
Details
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre