Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration

• Status: Recruiting
• Trial end date: 2025-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy. The main questions it aims to answer are:

1. Does high-dose insulin therapy improve liver function in the pre-operative setting?

2. What is the effect of high-dose insulin therapy on liver function and liver regeneration after a liver venous deprivation (LVD) procedure?

3. What is the relationship between volume hypertrophy and function in the regenerating liver? Participants will receive a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to assess its effect on liver function measured by 99m-Tc-Mebrofenin hepatobiliary scintigraphy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
• Treatments: Insulin

Criteria

Inclusion Criteria:

• Age > 18 years old

• Candidate for major liver resection

• Resectable colorectal liver metastasis

Exclusion Criteria:

• Inability to give consent

• Type 1 diabetes mellitus

• Uncontrolled blood glucose levels (fasting level > 10 mmol/L)

• Unresectable colorectal liver metastasis

• Extrahepatic metastatic disease that is unresectable