Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth

• Status: Completed
• Trial end date: 2018-05-15
• Target enrollment: 0
• Participant gender: All

Summary

The pulp necrosis of permanent immature teeth implies the interruption of the root formation and apical closure. Diode lasers have been used in many areas of dentistry, with tendency of good results in canal and dentine disinfection. The bactericidal effect of high-power lasers is based on dose dependent heat generation. Its antimicrobial effectiveness against diverse microorganisms has already been demonstrated. Photodynamic therapy (PDT) is a two-step therapeutic approach starting with the application of a photosensitizing agent and followed by irradiation with light energy that is spectrally matched to activate the drug. The balance between disinfection and the creation of an intracanal microenvironment conducive for the proliferation of stem cells requires further investigation. Aims of study are to compare the time required to obtain the clinical healing and the disappearance of clinical symptoms, and absence of periapical radiolucency, by using PDT and diode laser, with standard disinfection alone; to assess specificity of microbial load in permanent immature teeth, and root canal disinfection ability of PDT and diode laser, in compare with standard disinfection alone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Association of Paediatric and Preventive Dentists of Serbia
• Treatments: Eusol; Sodium Hypochlorite

Criteria

Inclusion criteria

• a non-vital permanent immature single rooted tooth

• primary endodontic infection

• 6 - 18 years old

• written informed consent obtained from each parent and child

Exclusion criteria

• uncontrolled diabetes mellitus,

• immunosuppression,

• severe asthma

• usage of antibiotics, anti-inflammatory, corticosteroid, or immunosuppressive therapy during the last 6 months

• need for antibiotics at current endodontic therapy

• need for antibiotics in prophylaxis of systematic disease before endodontic therapy

• periodontal diseases

• impossible adequate isolation of the tooth