Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus
Status:
Not yet recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin
(naturally occurring hormone that is made in the brain).
In this study healthy volunteers are recruited. Each study participant will have an IV
catheter placed. After placement of the IV catheter oxytocin will be given by IV infusion of
oxytocin or placebo (inactive solution). The investigators will perform some tests to
evaluate how oxytocin changes perceptions on the skin. The investigators will study a painful
perception by placing a probe on the skin and heating it to 116.6 degrees Fahrenheit for 30
seconds and a vibratory stimulus will be applied to the forearm with vibration begun at a 1
kHz frequency and decreased at a rate of 25 Hz/sec until the subject first perceives the
vibration. Each study participant will score any pain that is experienced on a 0 to 10 scale
and will report when the vibration is detected. Each participant will receive oxytocin and
placebo in a random order and will be blinded to group they are receiving.