Applying Shear Wave Elastography for Adjunct Steroid on Tuberculous Lymphadenitis

• Status: Recruiting
• Trial end date: 2025-12-01
• Target enrollment: 0
• Participant gender: All

Summary

1. To prospectively collect the radiologic data from the initial phase till the post-treatment phase of TB lymphadenitis.

2. To prospectively investigate the benefits of corticosteroid on reduction of paradoxical upgrading reaction in patients with tuberculous lymphadenitis based on the results of shear wave elastography.

3. To investigate the potential biomarker of host immunity in response to tuberculosis and predict the development of paradoxical upgrading reaction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Antitubercular Agents; Prednisolone

Criteria

Inclusion Criteria:

• Participants diagnosed of TB lymphadenitis.

• The diagnosis of TB lymphadenitis must qualify any of the following criteria:

1. microbiological evidence (culture or nucleic acid amplification test)

2. histology specimen featuring caseating granulomatous inflammation with acid-fast bacilli on smear, or clinical response to anti-TB therapy.

Exclusion Criteria:

• Participants with age < 18 years

• Diagnoses based on histologic report turned out to be non-tuberculosis mycobacterial infection

• The TB lymphadenitis involved was surgically removed, without available target to be monitored

• Participant under systemic (oral or parenteral) steroid therapy.

• Participant with active hepatitis B virus infection

• Participant reluctant to be enrolled in the trial