Aprepitant to Mitigate Opioids' Cognitive Side Effects

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Morphine and similar substances (called opioids) are often prescribed for moderate to severe pain, such as after a surgery, thus allowing for minimal pain and a better recovery. Unfortunately various, non-dangerous side effects from opioids occur often that limit the way patients feel and can take of themselves, despite otherwise good pain control and minimal limitations from the surgery itself.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Arizona
• Treatments: Aprepitant; Fosaprepitant

Criteria

Inclusion Criteria:

• healthy English speaking, opioid-naive consenting adults

Exclusion Criteria:

• current or very recent (< 3 months) opioid therapy

• morbid obesity

• liver disease

• therapy with pimozide, terfenadine, astemizole, cisapride, vitamin K antagonists (warfarin), hormonal contraceptives

• acute or chronic infections

• immunocompromised status

• hemodynamically unstable, hemorrhage (bleeding)

• recent surgery

• pregnancy, nursing

• younger than 18 years old

• not proficient of the English language