In the proposed study, investigators will conduct a 90-day dietary intervention study in
human subjects. Thirty individuals at risk for adenomatous colon polyp formation will be
randomized to receive a calcium and multi-mineral-rich natural product (Aquamin) or a
comparable level of calcium alone. There will also be a placebo group. Prior to ingesting the
study agents and following the course of treatment, colonic biopsies will be obtained by
sigmoidoscopy and quantitatively examined for markers of growth and differentiation. In this
study, metabolomic and microbial profiles will also be generated from fecal and colon mucosal
samples taken at baseline and study endpoint.