Are There Protective Effects of Antioxidants, Calcium Channel Blocker and Angiotensin Receptor Blocker Against Extracorporeal Shockwaves Lithotripsy Induced Renal Injury?

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will be conducted to evaluate the protective effects and mechanisms of antioxidants (vitamins A, C, E and Selenium), calcium channel blocker (Verapamil) and angiotensin receptor blocker (Lozartan) against shock wave induced renal injuries.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Angiotensin Receptor Antagonists; Antioxidants; Calcium; Calcium Channel Blockers; Calcium, Dietary; Losartan; Retinol palmitate; Selenium; Verapamil; Vitamin A; Vitamins

Criteria

Inclusion Criteria:

1. Well functioning kidney (serum creatinine <1.2 mg/dl).

2. Solitary renal stone.

3. Size: 25 mm or less in the largest diameter.

Exclusion Criteria:

1. Contraindications to ESWL

2. Previous surgical treatment of renal stones.

3. Congenital renal anomalies.

4. Pediatric patients (age <18 years).

5. Patients with Diabetes or hypertension