Argatroban Versus Lepirudin in Critically Ill Patients

• Status: Terminated
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the hypotheses that argatroban significantly increases efficacy and safety of renal replacement therapy measured as life time of haemodialysis filters as compared to lepirudin

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Heinrich-Heine University, Duesseldorf
• Treatments: Antithrombins; Argatroban; Hirudins; Lepirudin

Criteria

Inclusion Criteria:

• Thrombocytopenia suspicious for HIT with decrease in platelet count >50% from baseline obtained at hospital admission

• 4 T´s score for HIT probability >3 AND/OR positive ELISA for HIT

• Age ≥18 years

• Informed consent (if applicable)

Exclusion Criteria:

• Transient thrombocytopenia due to intraoperative bleeding

• Active bleeding

• Intracranial operations

• Liver dysfunction with spontaneous aPTT> 60 sec.

• History of adverse events or sensitivity against study drugs

• Pregnancy

• Age<18 years

• Preexisting psychiatric/neurologic disorders with long-term inability to provide informed consent