Aricept to Improve Functional Tasks in Vascular Dementia

• Status: Active, not recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Medications for memory improvement are available but they may not actually improve the ability to do real world tasks. The purpose of this research study is to determine if a medicine used to treat memory problems donepezil(Aricept) enhances the ability to remember steps of functional tasks and the actual ability to perform tasks relevant to real-life independence. Aricept is an FDA approved medication for the treatment of Alzheimer's disease. Aricept is an investigational drug for the purposes of this study, and is not approved for this purpose.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kessler Foundation
• Collaborator: Pfizer
• Treatments: Donepezil

Criteria

Inclusion Criteria:

1. I am 18 to100 yrs old.

2. I had one stroke 4 months to 5 yrs ago

3. I am not taking Aricept or other cholinesterase inhibitors (e.g. Exelon, Razadyne) or memantine (Namenda).

Exclusion Criteria:

1. I have history of dementia and or have been diagnosed with a memory disorder prior to my stroke.

2. I have been on anti-depressants or other cognitive enhancing drugs for less than 3 months and the dose is not stabilized yet.

3. I consume alcohol more than or equivalent of 4 ounces hard liquor weekly.

4. I am taking oral anticholinergic medications like Bethanechol, Bentyl or Detrol.

5. I am a woman of childbearing potential or I am pregnant or a nursing mother.

6. I have a history of chronic vomiting or diarrhea.

7. I am allergic to Aricept.