Aripiprazole Augmentation for Clozapine-Treated Patients With Refractory Schizophrenia

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether aripiprazole augmentation is safe and effective in the treatment of clozapine-treated patients with refractory schizophrenia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Collaborator: Korea Otsuka Pharmaceutical Co., Ltd.
• Treatments: Aripiprazole; Clozapine

Criteria

Inclusion Criteria:

• Male or female patients, 18-65 years of age.

• Patients must have a diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV).

• Female patients of menarche must be using a medically accepted means of contraception (e.g. oral contraceptives, Depo-Provera, abstinence).

• Each patient must provide written informed consent after full explanation of study protocol, and authorized legal guardian must understand the nature of the study and must also give assent to study participation.

• Patients must have a baseline (day 0) BPRS score of at least 35 or over 2 of 5 SANS global rating item scores of at least 3.

• Patients have been receiving clozapine treatment for more than 1 year and there has been no change in clozapine dosage for more than 3 months.

• Patients must have a history of antipsychotic treatment with at least 2 different kinds prior to clozapine administration.

• Subjects who are fluent in Korean.

Exclusion Criteria:

• DSM-IV substance (except nicotine or caffeine) dependence within the past 1 year.

• Female patients who are either pregnant or lactating.

• Mental retardation (IQ < 70).

• Neurological disorders including epilepsy, stroke, or severe head trauma.

• Clinically significant laboratory abnormalities, on any of the following tests: CBC with differential, electrolytes, BUN, creatinine, hepatic transaminases, urinalysis and EKG.

• Prior history of aripiprazole non-response or intolerance.

• BPRS score of < 35 and over 4 of 5 SANS global rating item scores of < 3.

• Participation in a clinical trial of another investigational drug within 3 months (90 days) prior to study entry.

• Treatment with an injectable depot neuroleptic within less than three dosing interval between the last depot neuroleptic injections and baseline (day 0).

• History of electroconvulsive therapy within the past 3 months.

• Subjects who are not fluent in Korean.