Despite the many behavioral and cognitive treatment therapies that exist for cocaine
addiction, individuals who complete cocaine abuse treatment are still at high risk for
relapsing. Aripiprazole, a medication that is currently used to treat schizophrenia, may be
useful in preventing drug relapse in individuals addicted to cocaine. This three-part study
will evaluate the interaction between aripiprazole and cocaine. It will also determine the
safety and effectiveness of aripiprazole in preventing drug relapse among cocaine addicts.