Artemisinin Resistance in Cambodia

• Status: Completed
• Trial end date: 2007-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The principal aim of this project is to investigate reports of developing artemisinin resistance in Cambodia using an integrated in vivo - in vitro approach to examine recent alarming reports of treatment failures with advanced combination therapies along the Thai-Cambodian border, which could have major impact on the malaria situation in the affected areas as well as the rest of the malaria-endemic world.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Vienna
• Collaborators: Armed Forces Research Institute of Medical Sciences, Thailand; Global Emerging Infections Surveillance and Response System; National Center for Parasitology, Entomology and Malaria Control
• Treatments: Artemisinine; Artemisinins; Artesunate

Criteria

Inclusion Criteria:

• Acute symptomatic falciparum malaria infection as determined by malaria smear with a parasite density of 100 to 100,000 asexual parasites/uL as determined on the screening smear with fever (defined as >=37.5ºC), or reported history of fever within the last 48 hours.

• Age: 18-65 years old

• Males or females. All females are required to have a negative human chorionic gonadotropin (hCG) pregnancy test (urine). All females of childbearing potential (not surgically sterile, or less than two years menopausal) are required to use an acceptable method of contraception, such as implant, injectable, oral contraceptive(s) with additional barrier contraception, intrauterine device, sexual abstinence, or vasectomized partner, throughout the study

• Written informed consent obtained

• Willing to stay under close medical supervision for the study duration of 28 days

• Otherwise healthy outpatients

Exclusion Criteria:

• Pregnant women, nursing mothers, or women of childbearing potential who do not use an acceptable method of contraception (as described in Inclusion Criteria, #3)

• Mixed malaria infection on admission by malaria smear

• A previous history of intolerance or hypersensitivity to the study drugs artesunate, quinine, or tetracycline or to drugs with similar chemical structures (quinidine, any artemisinin derivative, and tetracyclines)

• Malaria drug therapy administered in the past 30 days by history

• Previous participation in this trial, or participation in any other studies involving investigational or marketed products, concomitantly or within 30 days prior to entry in the study

• History of significant cardiovascular, liver or renal functional abnormality or any other clinically significant illness, which in the opinion of the investigator would place them at increased risk.

• Symptoms of severe vomiting (no food or inability to take food during the previous 8 hours).

• Signs or symptoms of severe malaria (as defined by WHO 2003)

• Unable and/or unlikely to comprehend and/or follow the protocol