Arthralgia of the Temporomandibular Joint. Pain Relief Following One Intra-articular Injection of Methylprednisolone

• Status: Completed
• Trial end date: 2017-03-15
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis is that a single dose intra-articular injection of corticosteroids are effective in relieving temporomandibular arthralgia pain.

The purpose of the study is therefore to evaluate the effect of a single dose intra-articular methylprednisolone vs. placebo in a month perspective on subjects with unilateral arthralgia of the TMJ.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Uppsala University
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• age 18 or above

• the diagnosis arthralgia in one TMJ

• understands Swedish both verbally and in written

• signed informed concent

Exclusion Criteria:

• TMJ sounds in terms of clicking (crepitation allowed))

• polyarthritis/connective tissue disease

• bilateral TMJ arthralgia

• fibromyalgia or other generalized pain

• ongoing infection

• ongoing dental treatment

• intra-articular corticosteroid injection of a TMJ the past 6 months

• previous surgery of the affected TMJ

• complex psychiatric/psychologic status

• institutionalized living including prisoners

• staff at the investigational clinic

• hypersensitive to local anesthetics

• hypersensitive to methylprednisolone

• hemophilia

• methemoglobinemia

• nursing

• compromized health status according to the judgment of the investigator

• concommitant use of the drugs cyclosporine, erythromycin, pentobarbital, itraconazole, ketoconazole, Rifampicin, Acetylsalicylic acid, Oral anticoagulant

• mentally retarded