Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
Oxygen radicals and inflammation are important causes for brain injury in neonates following
perinatal asphyxia. Animal studies demonstrated potential benefits to the brain when using
both of vitamin C and ibuprofen. The efficacy of these 2 drugs when combined in protecting
the human brain has not been studied. We aimed in this study to test the hypothesis that a
combination of anti-oxidants (vitamin C) and anti-inflammatory (ibuprofen) drugs can decrease
the brain injury in perinatal asphyxia and improve outcomes when given to infants immediately
after birth.