According to U.S. Pharmacist® "low-dose aspirin refers to dosages between 81 mg and 325 mg
taken every day to prevent heart attacks, strokes, and colon cancer." It has been found
through research that low-dose aspirin also decreases the risk of preeclampsia. The American
College of Obstetrics and Gynecologists (ACOG) recommends low-dose aspirin (81mg/day) for
women at high risk of preeclampsia. However, some researchers report that a dose of aspirin <
100 mg/day does not seem to decrease the risk of preeclampsia. Another trial studying
patients who are at a high risk for preterm preeclampsia, reported a reduction in the
occurrence of preeclampsia among patients taking aspirin at a dose of 150 mg.
The purpose of this pragmatic randomized study is to compare the difference in the
effectiveness of two doses of aspirin: 81 mg versus 162 mg in the prevention of preeclampsia
in pregnant women who are at a moderate to high risk for developing preeclampsia.