Aspirin Desensitization Registry in Patients With Aspirin Hypersensitivity
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Data about aspirin desensitization for patients with coronary artery disease undergoing
percutaneous coronary intervention are sparse.
This is a prospective, multicenter, observational study including 7 italian centers, to
assess safety and feasibility of a standard desensitization protocol in patients with aspirin
sensitivity undergoing coronary angiography. Patients with history of aspirin sensitivity
undergoing coronary angiography are prospectively enrolled.All patients underwent the
desensitization procedure with six sequential doses of aspirin (1, 5, 10, 20, 40, and 100 mg)
administered orally at predefined intervals, with the procedure lasting 5.5 hours.All
patients are followed for desensitization procedure success, description of reactions due to
the desensitization procedure, and in hospital major adverse cardiac events (MACE). All
patients are also followed-up for 12 months in order to assess their long-term risk of MACE,
compliance with ASA therapy, and late occurrence of side reactions due to ASA sensitivity.