Aspirin Statins Or Both For The Reduction Of Thrombin Generation In Diabetic People
Status:
Completed
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Despite formal recommendations, evidence of efficacy of aspirin in individuals with diabetes
is scant and controversial. While the efficacy of aspirin versus placebo in patients with
diabetes is currently under investigation in big randomized controlled trials, the putative
additive effects of aspirin and statins in this population remain to be investigated.
Moreover there are no data examining the pathophysiologic means by which aspirin with or
without statins affects thrombosis in diabetic patients.
The aim of this trial is to evaluate the efficacy of low-dose aspirin (100 mg/daily),
statins, both or neither for the reduction of thrombin generation. These preventive
strategies will be evaluated on the top of the other strategies aimed at optimizing the care
of diabetic patients in terms of metabolic control and control of the other cardiovascular
risk factors.