Aspirin Versus Clopidogrel Effect on Uterine Blood Flow in Women With Unexplained Recurrent Miscarriages

• Status: Unknown status
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The study will compare the effect of Aspirin versus clopidogrel effect on uterine perfusion in women with unexplained recurrent pregnancy loss with decreased uterine artery pulsatility index.

Null hypothesis: Women with recurrent miscarriage have the same blood flow after aspirin or clopidogrel treatment compared to their uterine artery pulsatility index before treatment.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Aspirin; Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• Women aged between 20 to 38 years old.

• Regular menstrual cycle (26 to 33 days).

• Women with 2 or more previous unexplained first trimester miscarriage.

• Impaired uterine perfusion (PI of uterine artery more than 2.5).

Exclusion Criteria:

• Known hypersensitivity to any of study medication components.

• Immunotherapy, endocrinotherapy, anticoagulant or anti-platelet management during the past 3 months