Assessing Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers
Status:
Terminated
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Buprenorphine, a treatment for opioid dependence, can be mixed with another drug, naloxone,
to limit abuse potential. Parenteral administration (intravenous or intramuscular injection)
of buprenorphine/naloxone causes withdrawal symptoms in opioid dependent individuals.
However, naloxone does not cause withdrawal symptoms in non-dependent opioid abusers. This
study will investigate whether naloxone decreases the opioid agonist effect from injected
buprenorphine, hence decreasing the abuse potential of buprenorphine/naloxone, in
non-dependent opioid abusers.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Buprenorphine Buprenorphine, Naloxone Drug Combination Naloxone